I agree with those who have said preferences are noted but not guaranteed. I always ask for non Smoking and do not always get it. That being said we own a condo in the MGM Signature in Las Vegas which is an entirely nonsmoking property even in the bar and on the balconys. If you must smoke you have to go outside. Or to the casino

In LV one would assume this policy costs us some rental income but we are almost always booked so clearly there is a market for this. Seems pretty analogous to Regent's new policy?
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Helen