The hotel I work for is a a non-smoking property. Upon check-in, guests are advised of our non-smoking policy. They are then required to sign an acknowledgement form which states that they have full knowledge of our hotel's smoking policy and will be charged $250 if they smoke in their guestroom or anywhere within the interior of our property. It's surprising to see how many guests smoke in their room, regardless of the ramifications.
Prior to booking any hotel, it's strongly suggested to inquire of that property's smoking policy if you're a smoker.