Anything is possible. We never went up the Amazon, but we had other problems. Triple check (or maybe quadruple check) as to whether you need (or don't need) a shot against yellow fever. We were given the wrong information by the consulate, and had to have them onboard the Mariner. Just a word to check it out so you don't have any problems. Since we came from SF, we did not have to declare medications, etc.
M.