In regard to the question of anyone having problems with the elevation in the Andes Mountains. My cousin's husband died there last year after a day of hiking in Cusco. He felt ill in the afternoon as did several other people in their group. He went to bed at night without seeing a doctor. When my cousin heard him up in the middle of the night he told her he felt really bad and the next thing she knew he was dead. The autopsy showed heart attack. The people of Peru were wonderful to her but all the red tape took a week before she could return to the USA with his coffin.
Friends of ours went on a Regent cruise since that time and they were fine at Machu Picchu.